High-fat Diets May Promote Prostate Cancer Metastasis, Mouse Study Suggests

High-fat Diets May Promote Prostate Cancer Metastasis, Mouse Study Suggests
Loss of two tumor suppressor genes – PTEN and PML – in prostate cancer appears to trigger the progression of disease by turning the cells into fat-producing factories, new research shows. These findings reveal the genetic link between aggressive types of prostate cancer and dietary habits and suggest new therapies for halting disease progression. The study, “An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer,” was published in the journal Nature Genetics. Fat-rich diets and obesity are established factors that promote cancer progression, including prostate cancer. Epidemiological data supports this claim and actually shows that metastatic prostate cancer is much higher in nations where high-fat diets are common, such as the United States. In fact, while in Asia only 10 percent of men develop prostate cancer, the rates are four times higher (40 percent) among Asian immigrants that come to live in the U.S. – similar to those of native-born U.S. men. This suggests that fat consumption is a key environmental trigger for aggressive forms of prostate cancer. "The progression of cancer to the metastatic stage represents a pivotal event that influences patient outcomes and the therapeutic options available to patients," the study's lead author, Pier Paolo Pandolfi, said in a press release. "Our data provide a strong genetic foundation for the mechanisms underlying metastatic progression, and we also demonstrated how environmental factors can boost these mechanisms to
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