Study Links High Receptor Levels to Reduced Survival in Diabetic Prostate Cancer Patients

Study Links High Receptor Levels to Reduced Survival in Diabetic Prostate Cancer Patients
High levels of the androgen receptor protein may play a role in the lower survival rate of men with both type 2 diabetes and prostate cancer, a study reports. The research, “Androgen receptor overexpression in prostate cancer in type 2 diabetes,” was published in the journal Molecular Metabolism. Contrary to what occurs in other diseases, men with type 2 diabetes do not have a higher incidence of prostate cancer. In fact, studies have shown they have a lower incidence. When men with type 2 diabetes do develop the cancer, however, their survival rate is significantly lower. This has perplexed researchers, who have been trying to find out why. Androgens, or male sex hormones, play an important role in the development of prostate cancer. A team of researchers wondered if analyzing major components of the androgen signaling pathway could yield clues about the link between type 2 diabetes and prostate cancer. They studied prostate cancer tissue samples from 70 men with type 2 diabetes and 59 men without diabetes. One thing they looked for was androgen receptor levels in the tissue. They also studied the production of key proteins involved in androgen signaling. One finding was increased levels of messenger RNA and androgen receptor protein levels in men with diabetes and prostate cancer. In addition, the team found a correlation between high levels of androgen receptor protein and high levels of the targets of its signaling, including the proteins PSA and PSMA. Researchers also found a link between high levels of the receptor an
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