BRCA2 Mutations Associated With Poor Prognosis in Prostate Cancer

BRCA2 Mutations Associated With Poor Prognosis in Prostate Cancer
BRCA2According to a recent study entitled “The impact of a BRCA2 mutation on mortality from screen-detected prostate cancer and published in the British Journal of Cancer, men with a BRCA2 mutation face an increased risk of prostate cancer. These types of mutations are associated with more aggressive tumors, leading to additional treatments to improve disease outcome. However, the effect of BRCA2 mutations' status on mortality in the setting of screen-detected cancers is still not defined. In this study, the authors analyzed 4187 Canadian men who underwent a prostate cancer biopsy for an elevated prostate-specific antigen (PSA) or an abnormal digital rectal examination between 1998 and 2010. Biopsies showed that 45.5% of men had prostate cancer (cases) and 54.5% were healthy (controls), with researchers following patients for death from prostate cancer until December 2012. The team sequenced the complete BRCA2 gene to look for possible mutations, finding a BRCA2 mutation in 1.4% of cases versus 0.4% of controls. Several differences were found between men with prostate cancer that screened positive or negative for the mutation, such as average age at diagnosis (67 vs 65 years), average PSA concentration at diagnosis (56.3 vs 13.3 ng/mL) and the proportion of men with h
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