Generex AE37 Prostate Cancer Vaccine Part of Recent Study

Generex AE37 Prostate Cancer Vaccine Part of Recent Study
Generex Biotechnology Corporation, a company focused on the research and development of drug delivery systems and technologies, has announced a follow-up study from its Phase I clinical trial of the immunotherapeutic agent AE37 in patients with prostate cancer. Prostate cancer is the second most common cancer in men worldwide, and the 6th leading cause of cancer-related death. According to The American Cancer Society, prostate cancer affects 233,000 men every year in the United States alone. In immunotherapy, prostate cancer is considered to be in the frontline, as it was the first indication for which an active systemic immunotherapy was granted approval by the FDA, with a number of immune-based cancer treatments currently being developed. The study, entitled “AE37 peptide vaccination in prostate cancer: identification of biomarkers in the context of prognosis and prediction” and published in the peer-reviewed journal Cancer Immunology, Immunotherapy aimed to predict the immunologic and clinical responses of vaccination therapy with AE37, a modified HER-2/neu peptide developed using the Antigen Express Ii-Key technology platform, responsible for triggering robust and specific CD4+ T cell activation. This peptide had already been used in the previous Phase I study in patients with prostate cancer and is currently being evaluated in a randomized Phase II trial to prevent recurrence in patients who have had breast cancer, a study that has showed promising results so far, especially in patients with low HER2 levels and in triple negative patients. The researchers analyzed data resultant from immunologic determinations before, during and after primary series of vaccinations with AE37, observing that the levels of transforming growth factor beta (
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