Killing More Cancerous Cells than Healthy at Thomas Jefferson University

Killing More Cancerous Cells than Healthy at Thomas Jefferson University
reataResearch in the laboratory of Ulrich Rodeck, MD, PhD, at Thomas Jefferson University, is looking to make prostate cancer (and other cancer types) radiation therapy safer and more effective for patients. Dr. Rodeck's work with a new anti-cancer drug, RTA-408, currently being developed by Reata Pharmaceuticals, is directed toward protecting normal cells from radiation while enhancing the effects of radiation on cancer cells. "It was really exciting to see that combining radiation and RTA-408 more effectively inhibited tumor growth compared to using either one or the other as single treatment modalities," said Dr. Rodeck in a news release from the university. He, along with Vitali Alexeev, PhD, and colleagues, conducted a series of experiments with potential anti-cancer compounds, radiation, and prostate cancer cells. The results were published in "Radiation Protection of the Gastrointestinal Tract and Growth Inhibition of Prostate Cancer Xenografts by a Single Compound," in Molecular Cancer Therapeutics. Of five different compounds administered to mice, RTA-408 proved to be most effective at protectin
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Maureen Newman is a science columnist for Pulmonary Hypertension News. She is currently a PhD student studying biomedical engineering at University of Rochester, working towards a career of research in biomaterials for drug delivery and regenerative medicine. She is an integral part of Dr. Danielle Benoit's laboratory, where she is investigating bone-homing therapeutics for osteoporosis treatment.

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