Trial Shows Safety of Vaccine Therapy for Prostate Cancer Patients

Trial Shows Safety of Vaccine Therapy for Prostate Cancer Patients
shutterstock_69262654An international team of researchers has shown that a specific vaccine therapy that activates a patient’s immune response can be safely administered to prostate cancer patients. The Phase II clinical study, published in the European Urology journal, evaluated this new vaccine in patients who had advanced prostate cancer diagnosed by increased prostate-specific antigen (PSA) and no visible metastasis, and whose cancer was resistant to hormone therapy. Furthermore, patients had already undergone surgery or radiation therapy. In the first part of the study, patients received PROSTVAC-V/TRICOM and PROSTVAC-F/TRICOM. The first is a vaccine that originates from a modified vaccinia virus that produces the PSA protein, helping to direct the patient’s immune response towards the PSA present in their prostate cancer cells. Additionally, this virus is genetically modified to produce 3 other proteins that augment the immune system’s capacity to locate and destroy cancer cells. PROSTVAC-F derives from the fowlpox virus and is endowed with the same genetic profile as PROSTAC-V, however it is administered several times to enhance the patient’s immune system. Men who enrolled in the trial were treated with one cycle of PROSTVAC-V/TRICOM followed by PROSTVAC-F/TRICOM for m
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *