Researchers Demonstrate Role Of Specific Protein in Prostate Cancer Progression

Researchers Demonstrate Role Of Specific Protein in Prostate Cancer Progression
shutterstock_138352340A recent study by Louisiana State University researchers has found that Rab7, a protein regulating lysosomal traffic, has tumor suppressive properties that can lower the invasion and metastatic potential of prostate cancer cells. Tumor invasion usually requires the secretion of proteolytic enzymes, which can occur via the constitutively active secretion pathway or through lysosome-localized proteases. Previous research has shown that the location of lysosomes within tumor cells is important for cell invasion. As such, when lysosomes are closer to the cell surface, there is an increase in secreted proteases and cell invasion. On the contrary, when lysosomes are located closer to the cell nucleus, tumor cells secrete fewer proteinases and are consequently less invasive. Cells need different types of GTPases, including Rab7, to regulate motor protein activity and therefore the distribution of lysosomes. Rab7 can regulate intracellular membrane trafficking and is linked to different types of disease, including cancer, as it can regulate apoptosis (cell death) in response to decreased growth factors. As such, this GTPase has been proposed as a potential tumor suppressor protein. In this new study, titled “Supporting a Role for the GTPase Rab7 in Prostate Cancer Progression
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