Patients With Persistent PSA After Prostatectomy Should Receive Earlier Aggressive Radiotherapy

Patients With Persistent PSA After Prostatectomy Should Receive Earlier Aggressive Radiotherapy
shutterstock_174165644According to a recent study published in the International Journal of Radiation Oncology • Biology • Physics, patients with prostate cancer that have persistent prostate specific antigen (PSA) after prostatectomy should receive earlier and more aggressive radiotherapy.  The study entitled “Prostate-Specific Antigen Persistence After Radical Prostatectomy as a Predictive Factor of Clinical Relapse-Free Survival and Overall Survival: 10-Year Data of the ARO 96-02 Trial,” provided a 10-year post-treatment analysis of the German ARO 96-02 prospective clinical trial, which compared a wait-and-see (WS, arm A) versus an adjuvant radiation therapy (ART, arm B) approach for patients with node negative prostate cancer who had a prostatectomy and achieved undetectable PSA levels. Moreover, the study conducted by Thomas Wiegel and colleagues reports the clinical outcome of patients who after 12 years of follow-up had persistent PSA post-radical prostatectomy and received aggressive radiotherapy (SRT, arm C). A total of 388 patients with prostate cancer were recruited from 1997 to 2004. All of the patients had radical prostatectomy. From the total 307 participants who achieved undetectable PSA levels, 159 patient
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Daniela holds a PhD in Clinical Psychology from The University of Edinburgh, United Kingdom, a MSc in Health Psychology and a BSc in Clinical Psychology. Her work has been focused on vulnerability to psychopathology and early identification and intervention in psychosis.


  1. Zorro says:

    The situation of residue prostate tissue left behind during a prostatectomy was not discussed.Sometimes the prostate enlarge into the bladder wall which causes the possibality that the urologist may not see it during surgery.This will certainly lead to confusing psa values.

    • Stacy says:

      I recently had prostate removed (9/16/18) and just had 1st follow up PSA (2/15/19) 5 months and my result came back at 1.74… I’m obviously concerned but recall my surgeon mentioning what you say above about some may be left behind or touched…. Obviously 1.74 isn’t undetectable but it is better than the 18 I had pre surgery. (52 years old btw, detected when 49)

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