Aduro and Janssen Initiate Prostate Cancer Clinical Trial

Aduro and Janssen Initiate Prostate Cancer Clinical Trial
prostate cancerPrivate immuno-oncology company Aduro Biotech Inc. recently announced that they will partner with Janssen Biotech Inc. on a series of toxicology studies to support an Investigational New Drug Application for ADU-741 in prostate cancer treatment. Prostate cancer is the second most common cancer among men in the United States. It is a curable cancer that usually features slow growth and affects older men. In fact, older age, race and a family history of the disease are risk factors for prostate cancer development. Aduro Biotech Inc. has developed a live attenuated double-deleted (LADD) Listeria monocytogenes bacteria system. Listeria bacteria has been studied and used for more than 50 years as a research tool in immunology. In Aduro’s system, the bacteria was engineered to encode and express specific tumor antigens, and conceived to be absorbed by the antigen presenting cells of the patient in order to trigger both a strong innate and a targeted adaptive immune response. This engineered immunotherapy can be used as a therapeutic agent against cancer. In addition, the LADD platform has a well-characterized safety profile based on multiple clinical trials conducted so far, and it can be used as a monotherapy or in combination with other therapi
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