Researchers Suggest a New Role for Glucocorticoid Receptor in Cancer Suppression

Researchers Suggest a New Role for Glucocorticoid Receptor in Cancer Suppression
shutterstock_86913998A new study led by researchers at the University of Manchester in the United Kingdom revealed that the glucocorticoid receptor in cells plays an additional role in coordinating cell division and is linked to cancer suppression. The study was published in the journal Proceedings of the National Academy of Sciences (PNAS) and is entitled “Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.” The glucocorticoid receptor (GR) is known to play a role in cell development, proliferation, metabolism and immune response. It is the receptor to which cortisol and other glucocorticoids bind to and is expressed in almost every cell in the body. The mechanism of action of several drugs is based on GR, such as prednisolone, a glucocorticoid widely used to treat several inflammatory and auto-immune disorders like asthma, rheumatoid arthritis and multiple sclerosis. Researchers have now found a new role for GR in chromosome segregation, a step in cell division or reproduction in which chromosomes pair off with their similar homologous chromosome. Researchers found that cell division was disrupted in cells where GR was absent an
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