New Research Focuses on Prostate Cancer Metastasis

New Research Focuses on Prostate Cancer Metastasis
Prostate cancer that metastasizes to the bone may be curable in the future using new research from the Pharmacology Department at Indiana University School of Medicine. Theresa A. Guise, MD, and her collaborator at the Center for Scientific Research and Higher Education at Ensenada, Pierrick G. J. Fournier, PhD, recently authored an article in Cancer Cell that explained how a protein involved in cell signaling pathways promotes bone metastasis in patients with advanced prostate cancer. "This finding could make a difference in how prostate cancer is treated in the future," said Dr. Fournier, in a news release from the university. "The unknown qualities of cancer frequently lead to aggressive treatments that are unnecessary. If we can determine a laboratory test that can serve as an indicator of the likelihood of progression or the severity of the disease, we could make better decisions about treatments and improve the quality of life for many patients." The protein is TGF-beta, which is integral to cell functions such as growth, proliferation, and death. It is also associated with bone metastases in breast cancer and melanoma, which is why Dr. Guise thought that interfering with TGF-beta may prevent metastasis in advanced prostate cancer patients. Prostate cancer patients also show high levels of another protein, PMEPA1, in their canc
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Maureen Newman is a science columnist for Pulmonary Hypertension News. She is currently a PhD student studying biomedical engineering at University of Rochester, working towards a career of research in biomaterials for drug delivery and regenerative medicine. She is an integral part of Dr. Danielle Benoit's laboratory, where she is investigating bone-homing therapeutics for osteoporosis treatment.

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