Specific Classes of RNA Potentially Linked to Prostate Cancer Progression

Specific Classes of RNA Potentially Linked to Prostate Cancer Progression
A study led by researchers at the University of Pittsburgh School of Medicine in Pennsylvania recently revealed that specific noncoding RNA molecules can play a role in prostate cancer development, the second most common cancer in men. The study is entitled “Noncoding RNAs that associate with YB-1 alter proliferation in prostate cancer cells” and was recently published in the journal RNA. The expression levels of the human Y-box binding protein 1 (YB-1), a highly conserved and multifunctional protein known to promote cellular proliferation, have been reported to correlate with drug resistance and poor clinical outcomes in several types of cancer. In breast cancer in particular, YB-1 was considered to be a powerful prognostic indicator. Now, YB-1 was found to be associated to a class of RNAs linked to cancer. “Many small RNAs known as microRNAs already have been shown to correlate with different grades of prostate cancer and could potentially serve as biomarkers for diagnosis and treatment,” explained the study’s co-senior author Dr. Bino John in a news release. “We did this study after computer models led us to hypothesize that there was a connection between YB-1 and microRNAs. What started out as a curiosity-driven experiment ended up being an exhilarating treasure hunt over four years, culminating in the discovery of two big molecular finds from human cells.”
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