Long Non-Coding RNA Induces Growth and Impairs Death in Prostate Cancer Cells, According to Study

Long Non-Coding RNA Induces Growth and Impairs Death in Prostate Cancer Cells, According to Study
Researchers at the University of Tokyo in Japan have shown that a long non-coding RNA (lncRNA) called a suppressor of cytokine signaling 2-antisense transcript 1 (SOCS2-AS1) may be involved in prostate cancer development by impairing cell death. lncRNAs are RNA molecules that do not code for a protein but are implicated in a variety of processes. The study, "Androgen-induced lncRNA SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells," was published in The Journal of Biological Chemistry. The androgen receptor (AR) and its signaling pathway have been shown to have a major role in the development and progression of both localized and advanced prostate cancer. In addition to surgery and radiotherapy, patients with high-risk localized prostate cancer are often treated with androgen deprivation therapies. However, most prostate cancers escape from androgen dependence and become what is known as castration-resistant prostate cancer (CRPC), revealing the need to identify the players in androgen receptor signaling to develop new targeted therapies. A number of lncRNAs have been linked with prostate cancer, including PCA3, PCGEM1, PCAT-1, and CTBP1-AS. CTBP1-AS, particularly, was described by researchers as an androgen-responsive lncRNA that promoted cancer progression. The researchers aimed at exploring other androgen-dependent lncRNAs that could have roles in prostate cancer progression. They used two prostate cancer cell lines and their corresponding castration-resistant cell lines, and examined their RNA expression with or without a
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *