Single Prostate Cancer Biopsy Not Enough to Guide Treatment, Study Finds

Single Prostate Cancer Biopsy Not Enough to Guide Treatment, Study Finds
Genetic analysis of a prostate cancer can be misleading if it is based on only one biopsy, according to a study that found large differences in how aggressive different tumors can be in the same patient, or even within different parts of the same tumor. The study, "Intratumoral and Intertumoral Genomic Heterogeneity of Multifocal Localized Prostate Cancer Impacts Molecular Classifications and Genomic Prognosticators," published in the journal European Urology, demonstrates that physicians should take care when basing treatment decisions on genetic analyses of prostate cancer. Although most prostate cancers are relatively harmless, some are aggressive and need more potent treatment. Genetic analyses of tumor tissue, so-called genomic fingerprinting, is increasingly being used by physicians to help them choose an appropriate treatment. To investigate if such an approach, based on only one biopsy, is feasible, a research team from the Cleveland Clinic analyzed tumors from four men who underwent radical prostatectomy, the removal of the entire prostate. Researchers took three biopsies from the main tumor (the tumor usually used for fingerprinting), and one each from smaller tumors within the prostate, and analyzed the tissue with various sequencing techniques. The team found that genetic changes in the tumors differed not only between tumors in the same patient, but more importantly,
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Magdalena holds an MSc in Pharmaceutical Bioscience and an interdisciplinary PhD merging the fields of psychiatry, immunology and neuropharmacology. Her previous research focused on metabolic and immunologic changes in psychotic disorders. She is now focusing on science writing, allowing her to culture her passion for medical science and human health.


  1. M Phuvie says:

    Is there a print button somewhere?
    I would like to save the article in print but can’t seem to find the print button?

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