Neem Plant Compound Seen to Treat Prostate Cancer and Its Metastasis in Animal Study

Neem Plant Compound Seen to Treat Prostate Cancer and Its Metastasis in Animal Study
A bioactive compound of the neem plant, a plant widely used in traditional Asian medicine, may be a promising treatment for prostate cancer, according to the results of a recent animal study. The study, "Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model," published in Antioxidants and Redox Signaling, shows that the compound, called nimbolide, can decrease prostate tumor size by up to 70 percent and cut tumor spread by half. Although prostate cancer is one of the most commonly diagnosed cancers worldwide, available therapies for metastatic prostate cancer are only marginally effective, and new treatment alternatives are needed to improve patient outcomes. "Although the diverse anti-cancer effects of nimbolide have been reported in different cancer types, its potential effects on prostate cancer initiation and progression have not been demonstrated in scientific studies," associate professor Gautam Sethi, with the Department of Pharmacology at the Yong Loo Lin School of Medicine at the National University of Singapore, and study's lead researcher, said in a press release. Recent studies had shown that both neem extracts and nimbolide could impair the proliferation and induce the death of prostate cancer cells. The researchers hypothesized that nimbolide was exerting such effects by targeting the oncogenic STAT3 pathway, which is highly activated in prostate cancer ce
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