Salmonella May Be Vehicle for Making Prostate Cancer Therapies More Effective

Salmonella May Be Vehicle for Making Prostate Cancer Therapies More Effective
A non-toxic Salmonella strain may be the key to treating a variety of cancers, including prostate cancer, according to a recent study published in PLOS One. The study, "Salmonella Bacterial Monotherapy Reduces Autochthonous Prostate Tumor Burden in the TRAMP Mouse Model2," used a mouse model of prostate cancer to show that a modified Salmonella typhimurium strain can penetrate the cell barrier of tumors and replicate inside them. "Salmonella strains have a natural preference for infiltrating and replicating within the cancer cells of a tumor, making the bacteria an ideal candidate for bacteriotherapy," Robert Kazmierczak, a senior investigator at the Cancer Research Center and a post-doctoral fellow in Division of Biological Sciences at the University of Missouri College of Arts and Science, said in a press release. "Bacteriotherapy is the use of live bacteria as therapy to treat a medical condition, like cancer." The idea of using bacteriotherapy for treatment of cancer was originally proposed more than a century ago, when researchers found that bacteria, pretreated with heat, could inhibit cancer growth. Attenuated Salmonella candidates have been extensively studied for targeted treatment of cancer, but recent clinical trials have shown excessive toxicity when Salmonella was used at high doses. Researchers have since focused on a way of lowering the toxicity of the Salmonella strain, while preserving i
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Inês Martins holds a BSc in Cell and Molecular Biology from Universidade Nova de Lisboa and is currently finishing her PhD in Biomedical Sciences at Universidade de Lisboa. Her work has been focused on blood vessels and their role in both hematopoiesis and cancer development.

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