Xtandi Combo Fails to Improve Survival in Advanced Prostate Cancer Patients in Phase 4 Study

Xtandi Combo Fails to Improve Survival in Advanced Prostate Cancer Patients in Phase 4 Study
Pfizer and Astellas Pharma announced that a Phase 4 clinical trial, investigating longer-term use of Xtandi (enzalutamide) as a combination treatment for patients with metastatic castration-resistant prostate cancer (mCRPC), did not reach its primary goal of improved progression-free survival. The trial is concluding but data will continue to be evaluated, the companies said. Top-line results failed to show that continued treatment with Xtandi, in combination with the chemotherapy drugs Zytiga (abiraterone acetate) and prednisone, led to better progression-free survival in chemotherapy-naive mCRPC patients whose PSA levels had progressed despite previous Xtandi therapy. “While the PLATO trial did not meet its primary endpoint, it is critical that we continue to focus on addressing the unmet needs of men with metastatic CRPC, who have a poor prognosis despite treatment advances,” Mohammad Hirmand, MD, chief medical officer at Medivation, a Pfizer company, said in a news release. “We will continue to analyze these data to better understand the results with the goal of further helping these patients.” Xtandi is an oral, once-daily androgen receptor inhibitor that blocks, using  three different steps, male hormones from signaling within tumor cells to prevent their growth. The U.S. Food and Drug Administration (FDA) approved Xtandi as a treatment for mCRPC patients in 2012, based on results from previous clinical trials showing a significant overall survival benefit with this drug. The Phase 4 PLA
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One comment

  1. Khalid Faidhi says:

    I’m stage 4 prostate cancer and utilizing the Xtandi medication for the past 5 months after i received the chemo therapy

    Is this mean,

    Am I, using the a treatment which add nothing to my case condition?..

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