Molecular Pathway That Promotes Aggressive Prostate Cancer Identified in Study

Molecular Pathway That Promotes Aggressive Prostate Cancer Identified in Study
A molecular pathway that promotes prostate cancer growth and resistance to anti-cancer therapy was identified in a new study. This finding could help design therapies targeting the molecular components of this pathway, which may become valuable options for patients with resistant prostate cancer. The study, “A Constitutive Intrinsic Inflammatory Signaling Circuit Composed Of miR-196b, Meis2, PPP3CC, And p65 Drives Prostate Cancer Castration Resistance,” was published in the journal Molecular Cell. Currently, the most efficient treatment for patients with advanced prostate cancer consists of depriving cancer cells of hormones, such as testosterone, which they need to survive and multiply. However, nearly all patients end up developing resistance to this treatment, which, given the lack of better options, leaves them with few alternatives. But scientists at The Scripps Research Institute in Florida identified a molecular pathway that seems to be involved in prostate cancer growth and resistance to treatment. This pathway, which is permanently active and has the ability to continually activate itself, is composed of several molecules, including the protein complex IκBα/NF-κB (p65). The IκBα/NF-κB complex controls the production of proteins in cancer cells, thereby supporting their survival and growth. Indeed, the NF-kB protein is known to contribute to cancer development and has been considered an important target for therapy. But this protein also has relevant roles in healthy cells, so therapies based on its direct inhibition may lead to undesired side effects. The pathway also includes the mi
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Joana brings more than 8 years of academic research and experience as well as Scientific writing and editing to her role as a Science and Research writer. She also served as a Postdoctoral Researcher at the Center for Neuroscience and Cell Biology in Coimbra, Portugal, where she also received her PhD in Health Science and Technologies, with a specialty in Molecular and Cellular Biology.

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