NanoVelcro Chip May Improve Prostate Cancer Monitoring via ‘Liquid Biopsies’

NanoVelcro Chip May Improve Prostate Cancer Monitoring via ‘Liquid Biopsies’
A new blood-analysis technique and a tiny device that detects circulating tumor cells in the blood may help doctors predict which cancers are likely to spread. Many technologies have been invented in recent years for capturing circulating tumor cells (CTCs) from whole blood. But one problem these technologies share is how to is keep the cells alive while removing them from the screening device. Researchers from Cedars-Sinai and UCLA are now conducting "liquid biopsies" by running blood through the NanoVelcro Chip, a device that has a hairy array of nanoscale wires, each with antibodies recognizing proteins from CTCs at the tips. As the blood passes by the wires, the CTCs stick to them. This technique, which earned researchers a place on the U.S. Cancer Moonshot program, could help clinicians monitor cancer-related changes in patients, including their response to treatments. "It's far better to draw a tube of blood once a month to monitor cancer than to make patients undergo repeated surgical procedures," Edwin Posadas, MD, medical director of the Urologic Oncology Program at Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute and one of the project's lead investigators, said in a news release. "The power of this technology lies in its capacity to provide information that is equal to or even superior to traditional tumor sampling by invasive procedures." According to the American Cancer Society, prostate cancer remains one of the
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