Mutations in SPOP Protein Trigger Onset of Prostate Cancer Subtype, Study Finds

Mutations in SPOP Protein Trigger Onset of Prostate Cancer Subtype, Study Finds
Mutations in a protein called SPOP trigger the development and growth of a subtype of prostate cancer, according to a study. The findings may lead to treatments targeting the subtype, researchers said. The study, “SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling,” was published in the journal Cancer Cell. Nearly 10 percent of prostate cancer patients carry SPOP mutations, but the protein's role in the development of the disease was not completely understood. Researchers at Weill Cornell Medicine found that SPOP mutations drive prostate cancer growth in a different way than
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