GRHL2 Protein Has Dual Role in Prostate Cancer, Researchers Find

GRHL2 Protein Has Dual Role in Prostate Cancer, Researchers Find
Researchers at the University of Adelaide in Australia have found that Grainyhead-like protein 2, called GRHL2, plays a dual role in prostate cancer by both promoting and preventing cancer growth. It also was found to be a regulator of the androgen receptor (AR), which is essential for the development of prostate cancer. While being key to the functioning of AR, GRHL2 also inhibits cellular mechanisms that are necessary for prostate cancer cells to spread to other organs. The study, “Novel androgen receptor co-regulator GRHL2 exerts both oncogenic and anti-metastatic functions in prostate cancer,” published in the journal Cancer Research, provide
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