GRHL2 Protein Has Dual Role in Prostate Cancer, Researchers Find

GRHL2 Protein Has Dual Role in Prostate Cancer, Researchers Find
Researchers at the University of Adelaide in Australia have found that Grainyhead-like protein 2, called GRHL2, plays a dual role in prostate cancer by both promoting and preventing cancer growth. It also was found to be a regulator of the androgen receptor (AR), which is essential for the development of prostate cancer. While being key to the functioning of AR, GRHL2 also inhibits cellular mechanisms that are necessary for prostate cancer cells to spread to other organs. The study, “Novel androgen receptor co-regulator GRHL2 exerts both oncogenic and anti-metastatic functions in prostate cancer,” published in the journal Cancer Research, provides new insight into the underlying mechanisms of aggressive castration-resistant prostate cancer and could lead to new treatment approaches. “We desperately need better therapies for this common killer of men. Our study provides important new insights into the biology of prostate cancer, which we aim to translate to new treatment strategies in the future,” Luke Selth, PhD, senior author of the study, said in a news release. The researchers found that GRHL2 was expressed in several models of prostate cancer, including drug-resistant tumors. In addition, its activity was essential for maintaining AR expression, promoting its activity, and inducing cancer cell growth. “The protein encoded by [GRHL2] appears to be vital for the function of the key driver of prostate cancer growth, the androgen receptor: it not only maintains levels of the androgen receptor, but also e
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