Mutations May Cause Prostate Cancer Patients to Become Resistant to BET Inhibitors, Study Says

Mutations May Cause Prostate Cancer Patients to Become Resistant to BET Inhibitors, Study Says
Mutations in the SPOP gene in prostate cancer are a reason patients often develop resistance to a class of treatment known as BET inhibitors, Mayo Clinic researchers report. This finding is in the study “Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation,” published in the journal Nature Medicine. BET

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