PSA Screening Lowers Mortality, Analysis of Clinical Trials Concludes

PSA Screening Lowers Mortality, Analysis of Clinical Trials Concludes
Prostate cancer screening using prostate-specific antigen (PSA) does reduce mortality in prostate cancer, according to a review that used a new approach to analyze data from large clinical trials. The findings suggest that current recommendations, which advise against PSA-based screening, might need to be revised, researchers write in their report, which was published in the journal Annals of Internal Medicine. Interestingly, the study, “Reconciling the Effects of Screening on Prostate Cancer Mortality in the ERSPC and PLCO Trials,” used the same source data that the U.S. Preventive Services Task Force (USPSTF) had employed to issue recommendations against screening. The studies were the European Randomized Study of Screening for Prostate Cancer (ERSPC; ISRCTN49127736) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO; NCT00002540). The ERSPC reported a 21 percent drop in prostate cancer mortality with screening, while the PLCO found no difference. But researchers from the Fred Hutchinson Cancer Research Center in Seattle and the University of Michigan, among many others, noted that the studies differed in key factors, including study design and adherence. For instance, the PLCO screened annually, while the ERSPC screened participants every two to four years. The PLCO also had a higher PSA threshold for referring patients for a biopsy and stopped screening after six r
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One comment

  1. cl dickinson says:

    Since I HAD prostate cancer (and a “focal procedure” to remove tumors) AND I am on testosterone replacement therapy, one would THINK that medicare might pay for a PSA test. Nope…. I’m on my second appeal now… (seems they are willing to gamble $114 a year against tens of thousands for my care if it comes back and I’m hospitalized)…
    Thats Government run “healthcare” for you

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