Cancer Can Change Tissue That Surrounds It, University of California Study Finds

Cancer Can Change Tissue That Surrounds It, University of California Study Finds
Tissue surrounding tumors can look normal, but its genetic composition may have changed in ways that help the cancer spread, a study reports. The key difference between the genetic makeup of the tissue after a tumor appears is that it contains more genes that can generate inflammation-promoting proteins. Increased inflammation can help the malignancy spread, according to the study, which included prostate cancer. University of California San Francisco researchers conducted the study, which was the first large-scale molecular-level analysis of tissue surrounding tumors. The research, published in Nature Communications, is titled "Comprehensive analysis of normal adjacent to tumor transcriptomes." The team discovered that changes in surrounding tissue can occur in several cancers. This highlights the changes' importance, they said. "Tumors secrete factors [substances] all around, changing nearby tissue and possibly even tissues that are far away," Dvir Aran, the study's lead author, said In a press release. Aran is a postdoctoral fellow at the university's Institute for Computational Health Sciences. In many cancer studies, researchers compare tumor tissue with that of tissue surrounding the tumor to look for changes occurring in the cancer tissue. The new findings suggest that while surrounding tissue may look normal, it may not be. To determine if tissue surrounding a tumor was as healthy as it looked, the researchers used data from the Cancer Genome Atlas. The atlas is a collaborative effort to collect, select, and analyze tissue for genomic alt
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