Study Furthers Understanding of Low Testosterone Levels in Prostate Cancer Risk

Study Furthers Understanding of Low Testosterone Levels in Prostate Cancer Risk
Men with very low testosterone levels are less likely to develop prostate cancer, but if they do, chances are they will develop an aggressive form of the disease, according to researchers at the University of Oxford. The findings were presented in November during the 2017 National Cancer Research Institute (NCRI) Conference, in Liverpool, U.K. The poster presentation was titled, “Low circulating free testosterone is associated with reduced incidence of prostate cancer: A pooled analysis of individual participant data from 20 prospective studies.” "This is an interesting biological finding that could help us understand how prostate cancer develops and progresses,” Tim Key, PhD, professor at the University of Oxford and co-author of the study, said in a press release. While prostate cancer needs testosterone to grow, little is known about how its levels influence risk for the disease. One hypothesis is that more testosterone only leads to increased tumor growth until all testosterone receptors are active in the cancer cells. After that, further increases in testosterone do not affect the rate of cancer growth. To test this hypothesis, researchers at the University of Oxford examined the records of men included in 20 prospective studies conducted between 1959 and 2004. Among the 19,021 participants, 6,933 developed prostate cancer. Participants
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