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Researchers Identify Gene Isoform Linked to Castration-resistant Prostate Cancer
Losing expression of a certain isoform of the HSD17B4 gene makes men more likely to get castration-resistant prostate cancer (CRPC), a lethal form of the disease that does not respond to treatment, a new study shows. The study, “Loss of an Androgen-Inactivating and Isoform-Specific HSD17B4 Splice Form Enables Emergence of Castration-Resistant Prostate Cancer,” appeared in the journal Cell