Zytiga Rejected in England as First-line Treatment for Newly Diagnosed Advanced Prostate Cancer

Zytiga Rejected in England as First-line Treatment for Newly Diagnosed Advanced Prostate Cancer
Janssen’s medication Zytiga (abiraterone) was recently rejected as a first-line treatment for newly diagnosed advanced prostate cancer on the National Health Service (NHS) in England following an initial draft recommendation from the National Institute for Health and Care Excellence (NICE). The negative recommendation means Zytiga won’t be made routinely available for men with newly diagnosed metastatic prostate cancer. As it is recommended now, Zytiga will only be prescribed through the NHS for these men once standard hormone treatment or chemotherapy has failed. In two recent Phase 3 trials – STAMPEDE and LATITUDE – first-line therapy with Zytiga along with steroids and hormone therapy was found to reduce the chance of cancer recurrence and improve survival, compared to hormone therapy alone. STAMPEDE (NCT00268476) is a Cancer Research UK-funded study that is investigating multiple treatment combination treatments for prostate cancer. The therapies are given as an add-on to standard first-line hormone therapy and compared to hormone therapy alone. Patients were all at high risk of their disease spreading, and treated earlier, before their disease become resistant to standard hormone therapy. After three years, 83 percent of patients taking Zytiga, prednisolone, and hormone therapy remained alive, compared to 76 percent in the control arm. Also, the combination reduced the risk of disease worsening or death by 71 percent. LATITUDE (NCT01715285) included men with prostate cancer whose cancer had already spread at the time of diagnosis but who had yet to receive hormone treatment. The LATITUDE trial compared patients treated with standard hormone therapy to those treated with hormone therapy plus Zytiga and the steroid prednisone. The
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