Phase 1/2 Trials Begin for PSMA-R2 Compounds Being Tested for Prostate Cancer Treatment, Diagnostics

Phase 1/2 Trials Begin for PSMA-R2 Compounds Being Tested for Prostate Cancer Treatment, Diagnostics
Two Phase 1/2 clinical trials testing PSMA-R2-based treatment and diagnostic candidates for prostate cancer have begun dosing their first patients, Advanced Accelerator Applications (AAA) announced in a press release. PSMA-R2 is a urea-based radioligand — a radioactive-labeled biochemical compound — of the protein prostate-specific membrane antigen (PSMA), which is frequently overproduced in prostate cancer cells. It is part of AAA’s theragnostic platform, a strategy that integrates diagnostics and therapeutics for cancer management. "Advancing PSMA-R2 into clinical studies is a major milestone for AAA," Germo Gericke, MD, head of research and development at AAA, said in the release. "We are eager to explore the full potential of this innovative platform in large patient populations, such as prostate cancer." The open-label, multicenter PROter trial (NCT03490838) is assessing 177Lu-PSMA-R2 for the treatment of patients with PSMA-positive, metastatic, castration-resistant prostate cancer, who received previous systemic treatment. The study will assess the treatment's safety, tolerability, and radiation dosimetry (the dosage absorbed by the body), while also further evaluating its effectiveness. While the first part of the trial will establish the recommended
Subscribe or to access all post and page content.

Tagged , , , , , , .

José is a science news writer with a PhD in Neuroscience from Universidade of Porto, in Portugal. He has also studied Biochemistry at Universidade do Porto and was a postdoctoral associate at Weill Cornell Medicine, in New York, and at The University of Western Ontario in London, Ontario, Canada. His work has ranged from the association of central cardiovascular and pain control to the neurobiological basis of hypertension, and the molecular pathways driving Alzheimer’s disease.

Leave a Comment

Your email address will not be published. Required fields are marked *