Early-onset Prostate Cancer Risk Higher Among Sub-fertile Men Using ICSI Technique, Study Finds

Early-onset Prostate Cancer Risk Higher Among Sub-fertile Men Using ICSI Technique, Study Finds
Sub-fertile men who require their sperm cells to be injected directly into an egg for conceiving have a much greater risk of developing prostate cancer, particularly its early-onset form, according to a large Swedish study. Although researchers rule out the procedure — intracytoplasmic sperm injection (ICSI) — as a direct cause of prostate cancer, they believe it could be a disease predictor. The research, “Risk of prostate cancer in ICSI treated man,” was presented at the recent European Society of Human Reproduction and Embryology (ESHRE) meeting in Barcelona, Spain. ICSI is used more commonly in couples dealing with male infertility, which may be due to factors such as low sperm counts, poor sperm mobility and quality, or no sperm in the male’s ejaculation. The technique involves the direct injection of sperm into eggs obtained from in vitro fertilization (IVF). The research team from Lund University in Sweden compared the risk of being diagnosed with prostate cancer in fathers who underwent ICSI, to those who had a child by natural conception (controls) and  fathers receiving routine IVF. The scientists first identified all fathers and their first child born, between 1994 and 2014, through information collected from the Swedish Cancer Registry, the Swedish Medical Birth Register, and the Swedish Quality Register for Assisted Reproduction. Among nearly 1.2 million fathers, they found 3,211 prostate cancer cases. Results showed t
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José is a science news writer with a PhD in Neuroscience from Universidade of Porto, in Portugal. He has also studied Biochemistry at Universidade do Porto and was a postdoctoral associate at Weill Cornell Medicine, in New York, and at The University of Western Ontario in London, Ontario, Canada. His work has ranged from the association of central cardiovascular and pain control to the neurobiological basis of hypertension, and the molecular pathways driving Alzheimer’s disease.

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