Study Uncovers How Genetic Mutation Causes Aggressive Forms of Prostate Cancer

Study Uncovers How Genetic Mutation Causes Aggressive Forms of Prostate Cancer
A type of mutation in a single nucleotide called rs11672691 plays a role in the development of aggressive prostate cancer by increasing the levels of two genes, PCAT19 and CEACAM21, a study has found. The study, “Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus,” was published in the journal Cell. Researchers have identified several risk factors involved in the development of prostate cancer, with genetic predisposition being one of the leading causes. Genome-wide association studies have implicated more than 100 single nucleotide polymorphisms (SNPs) — a type of mutation that changes a single DNA building block — in prostate cancer development. In particular, recent studies have identified the presence of the SNP rs11672691 in several cases of aggressive prostate cancer. This SNP is located within a gene called PCAT19, which creates a type of RNA molecule called a long non-coding RNA that plays a role in regulating the expression of other genes. However, the biological basis for the association between rs11672691 and prostate cancer development is not known. In this study, researchers at the University of Oulu in Finland set out to further investigate the association between rs11672691 and the development of prostate cancer in a group of 2,738 men diagnosed with prostate cancer. As shown previously
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Iqra holds a MSc in Cellular and Molecular Medicine from the University of Ottawa in Ottawa, Canada. She also holds a BSc in Life Sciences from Queen’s University in Kingston, Canada. Currently, she is completing a PhD in Laboratory Medicine and Pathobiology from the University of Toronto in Toronto, Canada. Her research has ranged from across various disease areas including Alzheimer’s disease, myelodysplastic syndrome, bleeding disorders and rare pediatric brain tumors.

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