Opdivo-Yervoy Combo Shows Signs of Activity in CRPC Patients with Metastases

Opdivo-Yervoy Combo Shows Signs of Activity in CRPC Patients with Metastases
A combination of Bristol-Myers Squibb’s immune checkpoint inhibitors Opdivo (nivolumab) and Yervoy (ipilimumab) reduces tumor burden in castration-resistant prostate cancer patients whose tumors have spread, interim Phase 2 results show. Findings from the CheckMate 650 trial (NCT02985957) were recently shared at the 2019 Genitourinary Cancers Symposium in San Francisco in a presentation titled, “Initial results from a phase II study of nivolumab (NIVO) plus ipilimumab (IPI) for the treatment of metastatic castration-resistant prostate cancer (mCRPC; CheckMate 650).” “The results from CheckMate 650 provide strong rationale for the development of combination immune checkpoint therapy for the treatment of prostate cancer, which is considered a cold tumor with few tumor-infiltrating lymphocytes,” Padmanee Sharma, MD, PhD, professor of genitourinary medical oncology and immunology at The University of Texas MD Anderson Cancer Center, said in a press release. “The clinical results from this study are encouraging and provide the foundation to test the combination strategy in a larger cohort of patients,” she said. Generally, prostate cancer tumors have very little infiltration of immune cells in their environment, which has lar
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