Prostate Cancer Patients May Safely Skip Radiation Therapy After Surgery, Phase 3 Trial Shows

Prostate Cancer Patients May Safely Skip Radiation Therapy After Surgery, Phase 3 Trial Shows
Men with prostate cancer who undergo surgery have similar long-term outcomes whether they receive radiation therapy shortly after the surgery or only when signs of disease recurrence appear, suggesting that some may be spared the radiation treatment, a Phase 3 clinical trial shows. Findings from the trial were shared in an oral presentation, titled “Timing of Radiotherapy (RT) After Radical Prostatectomy (RP): First Results from the RADICALS RT Randomised Controlled Trial (RCT) [NCT00541047],” at the European Society for Medical Oncology (ESMO) 2019 Congress, held recently in Barcelona, Spain. These are the late breaking results of the Phase 3 RADICALS-RT (NCT00541047) trial, designed to investigate if the addition of radiation therapy to androgen deprivation therapy (ADT) after prostate removal surgery improves the clinical outcomes of men with prostate cancer. The study enrolled 1,396 men who had undergone surgery to remove their prostate at several clinical centers across Canada, the U.K., Denmark, and Ireland. All participants were randomly assigned to receive one of two post-operative treatment regimens: either adjuvant radiotherapy, or observation only, with the option to reso
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