eRapa Leads to Boost in Immune Cells in Low-Grade Prostate Cancer Patients, Phase 1b Data Suggest

eRapa Leads to Boost in Immune Cells in Low-Grade Prostate Cancer Patients, Phase 1b Data Suggest
Daily treatment with a low dose of eRapa, Emtora Biosciences' new formulation of the therapeutic agent rapamycin, was safe and well tolerated, and led to immune system cell boosting in patients with low-grade prostate cancer, according to data from a Phase 1b clinical trial. The findings were presented in a poster at the 2020 Clinical Immuno-Oncology Symposium of the American Society of Clinical Oncology and Society for Immunotherapy of Cancer in Orlando, Florida. The study was titled, "Results of a phase Ib trial of encapsulated rapamycin in prostate cancer patients under active surveillance to prevent progression." Activation of mTOR — a protein kinase involved in cell proliferation and survival — has long been known to influence prostate cancer growth and metastasis, making it a promising target for cancer therapy. Rapamycin, a naturally occurring chemical that inhibits mTOR, and its analogs have been successfully applied to treat specific cancers in the clinic. But despite its potential, rapamycin has shown low
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