Teams Working in Advanced Cancer Win 2020 PCF Challenge Awards

Teams Working in Advanced Cancer Win 2020 PCF Challenge Awards
The philanthropic organization Prostate Cancer Foundation (PCF) and the charity Movember Foundation have announced the winners of the 2020 PCF Challenge Awards, an initiative that supports promising research in the pursuit of a cure for prostate cancer. The awards total $2 million, of which $792,000 came from the 2019 Movember U.S. Campaign and $477,000 were raised during the 2019 Distinguished Gentleman's Ride. “The intent of the PCF Challenge Award is to support ambitious team science with the potential to develop new treatments for metastatic prostate cancer,” Howard Soule, PhD, executive vice president and chief science officer of PCF, said in a press release. The PCF Challenge Awards were given to two research teams, one led by Arul Chinnaiyan, MD, PhD, at the University of Michigan, and the other by Phuoc Tran, MD, PhD, at the Johns Hopkins University. "We congratulate Drs. Chinnaiyan and Tran and their colleagues on their research which we believe has the potential to develop new therapeutic approaches for advanced prostate cancer and provide more options for patients in need," Soule said. Chinnaiyan, together with his principal and co-investigators, have identified a promising new approach for advanced and treatment-resistant prostate cancer that targets cancer-driving regulators of gene expression. In this research project, Chinnaiyan’s research team will first study the mechanism of action of a new agent they identified, and in preclinical work look for early evidence of effectiveness. They then plan to lead an early clinical trial testing the agent, alone and in combinations, in patients with metastatic castration resistant prostate cancer. Tran and his team members will use samples taken from patients in two clinical trials they a
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