Prostate cancer is the most common non-skin cancer in America, affecting 1 in 7 men. But who is most at risk of getting prostate cancer and why? Risk factors for the development of prostate cancer are not an exact science since there is more than one type of prostate cancer. As an example, the factors that may influence the development of low-risk prostate cancer may not be the same risk factors for aggressive prostate cancer. We’ve put together nine possible risk factors for aggressive prostate cancer (source: Prostate Cancer Foundation website): 1. Body mass index Read more about how a novel family gene could be linked to the development of prostate cancer.