Study Finds Expression of miR-21 Can Predict Biochemical Failure in Prostate Cancer Patients

Study Finds Expression of miR-21 Can Predict Biochemical Failure in Prostate Cancer Patients
shutterstock_150591119In a recent study titled “Stromal Expression of MiR-21 Predicts Biochemical Failure in Prostate Cancer Patients with Gleason Score 6”, published in PlosOne, a group of researchers from the University Hospital of North Norway, saw that high stromal expression of miR-21 was related to poor biochemical recurrence-free survival after radical prostatectomy (RP) in prostate cancer patients. MicroRNAs are responsible for regulating protein expression and their role in prostate cancer, along with many other neoplastic diseases, is the subject of several ongoing studies. The research team, led by Dr. Elin Richardsen, wanted to explore the miRNA profile in prostate cancer tissue, to understand the link with clinicopathologic data and study the potential of using miRNAs as diagnostic and prognostic markers of disease. From a total of 535 patients who underwent RP, 30 patients (14 with rapid biochemical failure (BF) and 16 without), were analyzed. Using microarray hybridization, the team quantified 1435 miRNAs, selecting those with the highest standard deviation to be validated by real time polymerase chain reaction (PCR). Furthermore, expression of miR-21 was assessed using
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