Site of Prostate Cancer’s Spread Can Determine Survival Over Time, Study Reports

Site of Prostate Cancer’s Spread Can Determine Survival Over Time, Study Reports
Once prostate cancer metastasizes, a person's chances of survival diminish. But in an extensive analysis, Duke University Medical Center researchers found that the location of the cancer's spread has a large impact on survival — a finding that could guide future treatment approaches. “Smaller studies had given doctors and patients indications that the site of metastasis in prostate cancer affects survival, but prevalence rates in organ sites were small, so it was difficult to provide good guidance,” Susan Halabi, professor of biostatistics at Duke and lead study author, said in a press release. The study, titled Meta-Analysis Evaluating the Impact of Site of Metastasis on Overall Survival in Men With Castration-Resistant Prostate Cancer and published online in the Journal of Clinical Oncology, is the largest of its kind. The research team analyzed previously published data from of 8,736 patients treated at cancer centers worldwide as part of nine large Phase 3 clinical trials of metastatic prostate cancer. All men had received standard chemotherapy with the drug docetaxel, excluding the possibility that the survival times were influenced by different treatments. For the analysis, researchers divided metastases into four groups: lung, liver, lymph nodes only, and bone with or without lymph nodes. While lymph metastases affected only 6.4 percent of study patients
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