Study Uncovers Why BRCA2-mutant Prostate Tumors Are So Aggressive

Study Uncovers Why BRCA2-mutant Prostate Tumors Are So Aggressive
Men who carry mutations of the tumor-suppressor gene BRCA2 are at higher risk of developing prostate cancer, and chances are they will have a more aggressive form of the disease, but researchers have only now understood why this happens. A recent study has shown that BRCA2 mutations trigger genetic changes in prostate tumors that resemble those seen in metastasis -- or cancer spreading to other organs. The mutations lead to more aggressive disease and poorer prognosis. The research emphasizes the importance of genetic testing in prostate cancer, which can improve personalized treatment and lead to better outcomes. The study, "Germline BRCA2 mutations drive prostate cancers with d
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