Steroid Estetrol Reduces High Testosterone Levels Associated with Prostate Cancer

Steroid Estetrol Reduces High Testosterone Levels Associated with Prostate Cancer
A steroid called estetrol that is produced only by a fetus' liver during pregnancy could be used to treat prostate cancer, either by itself or in combination with other hormone therapies, according to a study. The findings on estetrol, or E4, were presented at ENDO 2017, the Endocrine Society's 99th annual scientific meeting. The study, titled “The Effects of the Human Fetal Estrogen Estetrol (E4) in Healthy Men to Estimate Its Potential Use for the Treatment of Prostate Cancer,” was done by a Dutch research team. "E4 for the treatment of prostate cancer would offer a new and affordable option compared to current standard and new therapies,” Ellen Dutman, the lead author of the study, said in a press release Hormone therapy is a standard treatment for patients with prostate cancer. It involves inhibiting testosterone’s pro-tumor effects by reducing its level in the blood. To evaluate the effects of E4 on testosterone levels, the research team conducted a Phase 1 placebo-controlled trial (NCT02718378). Thirty healthy volunteers 40 to 70 years old received oral E4 in either 20-mg or 40-mg doses, or a placebo, for 28 days. Both doses reduced testosterone levels. E4 also impacted the levels of two of the three other hormones involved in prostate cancer progression. It reduced levels of FSH, and increased levels of SHBG. Levels of LH remained the same. Both E4 doses we
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