Steroid Estetrol Reduces High Testosterone Levels Associated with Prostate Cancer

Steroid Estetrol Reduces High Testosterone Levels Associated with Prostate Cancer
A steroid called estetrol that is produced only by a fetus' liver during pregnancy could be used to treat prostate cancer, either by itself or in combination with other hormone therapies, according to a study. The findings on estetrol, or E4, were presented at ENDO 2017, the Endocrine Society's 99th annual scientific meeting. The study, titled “The Effects of the Human Fetal Estrogen Estetrol (E4) in Healthy Men to Estimate Its Potential Use for the Treatment of Prostate Cancer,” was done by a Dutch research team. "E4 for the treatment of prostate cancer would offer a new and affordable option compared to current standard and new therapies,” Ellen Dutman, the lead author of the study, said in a press release Hormone therapy is a standard treatment for patients with prostate cancer. It involves inhibiting testosterone’s pro-tumor effects by reducing its level in the blood. To evaluate the effects of E4 on testosterone levels, the research team conducted a Phase 1 placebo-controlled trial (NCT02718378). Thirty healthy volunteers 40 to 70 years old received oral E4 in either 20-mg or 40-mg doses, or a placebo, for 28 days. Both doses reduced testosterone levels. E4 also impacted the levels of two of the three other hormones involved in prostate cancer progression. It reduced levels of FSH, and increased levels of SHBG. Levels of LH remained the same. Both E4 doses we
Subscribe or to access all post and page content.

One comment

  1. Lawrence Glickman says:

    Is there any doubt that associative trials are worthless? This one is a great example. Hormone therapy is now under serious study for high dose testosterone combined with alternate hormone starvation. In addition if high testosterone were the real cause of prostate cancer every 18 year old male would have prostate cancer. Clearly the fall of regular testosterone and relative rise of estrogen and the DHT variant of testosterone is certainly a more viable hypothesis. Sadly the new harmful publicity concerning “Watchful Waiting” leads some men to avoid treatment in the early stages when it is most treatable and leads to “Hormone starvation therapy” which usually means the cancer has spread and the prognosis is slow death.

Leave a Comment

Your email address will not be published. Required fields are marked *