Common Cat Parasite Toxoplasma Gondii May Trigger Prostate Cancer, Mouse Study Shows

Common Cat Parasite Toxoplasma Gondii May Trigger Prostate Cancer, Mouse Study Shows

Toxoplasma gondii, a parasite commonly transmitted through cat feces, causes prostate cancer in mice by inflaming the prostate, suggests a study recently published in the journal The Prostate.

Authors of the study, “The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model,”  urged cat owners to take extra care when cleaning litter trays.

Prostatic inflammation is characteristic of diseases like benign prostatic hyperplasia (BPH) and prostate cancer, both very common in older men.

Factors already known to inflame the prostate include certain viruses, bacteria and steroids, as well as environmental and dietary factors. However, scientists aren’t sure of the particular role each factor plays in promoting prostatic inflammation.  T. gondii, which infects most mammals, is present throughout the world; infection rates reach 80 percent in some countries.

Once patients are first infected with T. gondii, the parasite rapidly divides in the body and causes toxoplasmosis, which leads to mild flu-like symptoms. Eventually, T. gondii becomes a lifelong infection as it stays silently in the patient in the form of a tissue cyst called a bradyzoite. Since it causes its host no harm to the host, T. gondii has not received widespread scientific attention.

In an effort to induce inflammation, researchers infected male mice with T. gondii and determined inflammation by analyzing two factors. First, they looked at the number and severity of infiltrating immune cells into the prostate, which is the main characteristic of inflammation. Second, they studied the proliferation of epithelial cells, which lihe prostate and lead to both BPH and prostate cancer.

Results showed that T. gondii infected the mouse prostate within the first 14 days of infection and established bradyzoite tissue cysts for at least 60 days. This infection caused a substantial inflammatory reaction in the prostate as well as reactive hyperplasia. This refers to the formation of multiple layers and the abnormal appearance of prostate epithelial cells, accompanied by the infiltrating inflammatory cells.

This study was the first to demonstrate that T. gondii can trigger prostatic inflammation in any species. As a result, researchers developed a new mouse model to study prostatic inflammation without the need to genetically manipulate the mice — thus lending greater credibility to the results.

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