BMS and Clovis to Study Opdivo, Rubraca Combo Treatment in Prostate, Other Cancers

BMS and Clovis to Study Opdivo, Rubraca Combo Treatment in Prostate, Other Cancers
Bristol-Myers Squibb and Clovis Oncology will collaborate to assess the combination of Opdivo (nivolumab) and Rubraca (rucaparib) in Phase 2 and 3 clinical studies in patients with different cancer types, including prostate cancer. The companies plan to launch a Phase 2 study to investigate the safety and effectiveness of the combo treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). All studies are expected to begin before the end of 2017. “We are very enthusiastic about studying Rubraca and Opdivo in combination, and the potential to create new treatment options for patients with multiple tumor types, as well as for patients beyond those with BRCA mutations,” Patrick J. Mahaffy, Clovis Oncology’s president and CEO, said in a press release. “This substantial clinical collaboration in ovarian, triple-negative breast and prostate cancers represents a significant effort by Clovis and Bristol-Myers Squibb to realize that potential,” he said. Fouad Namouni, MD, Bristol-Myers Squibb’s head of oncology, said the collaboration with Clovis "addresses areas of unmet medical need where the combination of Opdivo and Rubraca may lead to an additional treatment option for patients with difficult to treat cancers." "We are committed to investigating a wide range of oncology therapies and look forward to studying the combination of Clovis’ PARP inhibitor and our immunotherapy," Namouni added. Cancer cells are constantly multiplying, but the division process is sometimes associated with errors that may cause their
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