Erleada Improves Survival in Metastatic Castration-Sensitive Prostate Cancer, Phase 3 Trial Finds

Erleada Improves Survival in Metastatic Castration-Sensitive Prostate Cancer, Phase 3 Trial Finds
Adding Janssen's androgen receptor inhibitor Erleada (apalutamide) to first-line androgen deprivation therapy (ADT) significantly extended survival and delayed disease progression or death in metastatic castration-sensitive prostate cancer patients included in a Phase 3 trial — meeting the study's two primary objectives. Based on the findings, an independent data monitoring committee has recommended that the TITAN trial be unblinded — so both patients and physicians know who is getting which treatment — and that patients on only ADT be given the chance to cross over to the active treatment. "The TITAN study was designed to evaluate the efficacy and safety of Erleada in combination with androgen deprivation therapy in patients with newly-diagnosed metastatic castration-sensitive prostate cancer, regardless of the extent of their disease," Margaret Yu, MD, vice president of oncology clinical development at Janssen research and development, said in a press release. Metastasis is a major cause of complications and death among men with prostate cancer. Once prostate cancer spreads, patients tend to have a poor prognosis, even if their cancer still responds to hormone therapy — termed castration-sensitive pro
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