68Ga-PSMA-11 PET Scan Accurate, Safe in Detecting Recurrent PC, Study Says

68Ga-PSMA-11 PET Scan Accurate, Safe in Detecting Recurrent PC, Study Says
68Ga-PSMA-11 PET scans are highly accurate, reproducible, and safe for detecting prostate cancer that has come back after prior therapy with prostate surgery or radiation therapy, a study shows. The report, "Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer," was published in the journal JAMA Oncology. In men whose prostate cancer has come back — seen by a rise in prostate-specific antigen (PSA) blood tests — international guidelines recommend computed tomography (CT), magnetic resonance imaging (MRI), and bone scans to visualize the cancer's location and whether it has spread. But these imaging techniques may have low sensitivity, specifically when PSA levels are low. Thus, researchers have been developing tracers for positron emission tomography (PET) imaging that light up prostate cancer before it is evident on other imaging tests. PET scans use probes called radiotracers, which are specific molecules linked to or "labeled" with a small bit of radioactive material, making them detectable on the scan. The non-radioactive part of a radiotracer is a molecule designed to accumulate in cancers or regions of inflammation, or bind specific proteins in the body. Several studies have demonstrated that one PET probe — 68Ga-PSMA-11 — yields "unprecedented accuracy and effect on treatment," researchers noted. It is composed of a molecule that binds the prostate specific membrane antigen (PSMA), labeled with the radioactive compound gallium (68G). Although this technique has been used on a compassionate basis and evaluated in multiple case studies outside the U.S., there is a lack of prospective data — a study that watches for outcomes over the study period, rather than looking at data obtained in the past (retrospective stud
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