Enrollment Completed for Phase 3 Trial Testing Provenge in Prostate Cancer Patients on Active Surveillance

Enrollment Completed for Phase 3 Trial Testing Provenge in Prostate Cancer Patients on Active Surveillance
Dendreon Pharmaceuticals has completed patient enrollment ahead of schedule in an ongoing Phase 3 trial assessing the safety and efficacy of its immunotherapy Provenge (sipuleucel-T) for men with early-stage prostate cancer on active surveillance, the company announced. The open-label ProVent trial (NCT03686683) included more than 450 participants from approximately 60 sites across the United States. Patients were randomly assigned to one of two groups: those who continued on active surveillance as standard of care (control group), and those given three infusions of Provenge at approximately two-week intervals. “The rapid pace of enrollment in the ProVent trial is a significant milestone for Dendreon, and underscores a strong interest by patients and physicians in the potential clinical benefit of sipuleucel-T in men on active surveillance,” Bruce A. Brown, MD, chief medical officer at Dendreon, said in a press release. Prostate cancer is the most common cancer among men, but a great number of cases will remain dormant and not progress to significant disability or risk of mortality. In these cases, active surveillance — an approach that consists of actively monitoring the cancer to detec
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