High Blood Levels of 2 Hormones May Be Linked to Prostate Cancer Development, Study Says

High Blood Levels of 2 Hormones May Be Linked to Prostate Cancer Development, Study Says
High blood levels of two hormones — insulin-like growth factor-I (IGF-I) and free testosterone — are associated with increased risk of prostate cancer later in life, a new study suggests. The study, “Serum hormones and prostate cancer incidence and mortality in UK Biobank,” was presented at the recent 2019 National Cancer Research Institute (NCRI) Cancer Conference. Worldwide, prostate cancer is the  most common cancer in men after lung cancer, and a leading cause of cancer-related death. Modifiable risk factors can help men reduce their chances of developing the disease, but are not well-established. The growth hormone IGF-I and testosterone have been implicated in the development and progression of this cancer, but their relationship is not fully understood. “We were interested in studying the levels of [these] two hormones circulating in the blood because previous research suggests they could be linked with prostate cancer and because these are factors that could potentially be altered in an attempt to reduce prostate cancer risk,” Ruth Travis, an associate professor at the University of Oxford and one of the study's lead authors, said in a press release. Researchers set out to investigate the link between circulating blood concentrations of IGF-I, free (or biologically active) testosterone, total testosterone, and the sex hormone binding globulin (SHBG), and prostate cancer incidence and mortality in a large British cohort. They studied 200,452 men taking part in the U.K. Biobank. All did not have cancer, were not receiving hormone therapy at the time they began this study, and had given blood samples tested for hormone levels at baseline (study's start). A subset of 9,000 men gave a second blood sample at a later date, which hel
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