Prostate Cancer Risk Influenced By Second And Third Degree Relatives’ History of The Disease

Prostate Cancer Risk Influenced By Second And Third Degree Relatives’ History of The Disease
New research led by Huntsman Cancer Institute investigators and published in the The Prostate journal, has shown that looking into a man’s more complete family history, uncles and great-parents, can be of crucial value to decide if a PSA test is appropriate for prostate cancer detection. “Family history is a substantial risk factor for prostate cancer,” Lisa Cannon-Albright, PhD, professor of genetic epidemiology and an HCI investigator said in a news release. “But typically, a clinician will ask a patient whether there are any people in the family with prostate cancer, possibly identifying whether they are first-degree relatives. And that’s about as far as it goes.” The team of researchers analyzed data from the Utah Population Database, that links genealogic and medical information for over 7.3 million individuals, and created a personalized risk estimative for men by looking into their family prostate cancer history (first-, second-, and third-degree relatives). The individualized relative risks for men who had a family history of prostate cancer were calculated based on the number, degree, and age at diagnosis of their affected ancestors. The team then pinpointed combinations of these factors that were associated with a greater than two and three-fold risk of developing prostate cancer. The results showed that two-thirds of Utah men have an increased risk of prostate cancer due to their family history of the malignancy. However, there are only a small number of men who are considered to be at high risk. “The clinical application of our findings is especially relevant because there is no consensus on prostate cancer screening,” co-author Robert A. Stephenson, MD, professor of urologic oncology at the U of U and an HCI investigator
Subscribe or to access all post and page content.