Testosterone Therapy Can Benefit Advanced Prostate Cancer Patients

Testosterone Therapy Can Benefit Advanced Prostate Cancer Patients
shutterstock_83348491A recent study published in Science Translational Medicine by Johns Hopkins Kimmel Cancer Center researchers has found that testosterone can suppress some types of advanced forms of prostate cancer, while reversing resistance to testosterone-blocking drugs. Researcher Samuel Denmeade, M.D., oncology professor at the Johns Hopkins University School of Medicine, led the study of a total of 16 patients suffering from metastatic prostate cancer and highlighted that one of the most important aspects of this research was related to the timing of testosterone treatment, advising that patients should not self-medicate with testosterone supplements available in pharmacies. Earlier studies have shown addressing testosterone with a wrong timing could actually exacerbate the disease. Usually, to treat advanced prostate cancer, physicians use drugs that can stop testosterone production. However, cancer cells tend to gain resistance to these drugs and the treatment strategy usually changes to drugs like enzalutamide, which can impair testosterone’s capacity to interact with receptors present in prostate cancer cells. Combining these two types of drugs (androgen deprivation therapy) is susceptible to increase cancer aggressiveness throughout time and can lead to
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