New Prostate Cancer Genetic Variants Identified In microRNAs

New Prostate Cancer Genetic Variants Identified In microRNAs
shutterstock_202719580In a new study entitled “A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer,” researchers discovered genetic variations within miRNA binding sites that are associated with increased risk for prostate cancer. The study was published in the journal Cancer Discovery. A group of scientists at the Moffitt Cancer Center participated in a study through the PRACTICAL consortium (short for Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) that intended to identify additional genetic variants associated with higher risk of prostate cancer development, as the current known genetic variations (approximately 100) only explain 33 percent of the increase risk in prostate cancer within families. To this end, the authors performed a large-sale genetic analysis in individuals participating in 23 clinical studies, including in total 22,301 prostate cancer cases and 22,320 normal controls, and focused their genetic analysis on genes affecting miRNA binding (miRSNP). microRNAs are a class of small non-c
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