Permanent Radiotherapy Implants Reduce Risk Of Prostate Cancer Recurrence By 5 Years

Permanent Radiotherapy Implants Reduce Risk Of Prostate Cancer Recurrence By 5 Years
Recent results of a controlled, randomized clinical trial comparing the use of permanent radioactive implants (brachytherapy) with external beam, dose-escalated radiotherapy in individuals suffering with prostate cancer revealed that patients who received brachytherapy were 2 times more likely to be cancer-free 5 years after treatment. The results were presented by James Morris, professor at the Department of Radiation Oncology, Vancouver Cancer Centre, British Columbia Cancer Agency (BCCA), Vancouver, Canada, during the 3rd ESTRO Forum in Barcelona, Spain. The ASCENDE-RT1 trial is the first and only study comparing low-dose-rate prostate brachytherapy (LDR-PB) to address treatment of prostate cancer with any kind of radiation therapy delivery method. A total of 398 men diagnosed with cancer not yet spread to other zones outside the prostate gland were enrolled in the trial. These men, based on several features of the cancer, were at high risk of treatment failure. At first, individuals received androgen deprivation therapy (ADT), aimed to reduce levels of male hormones that stimulate prostate cancer cells to grow. After 8 months of receiving ADT, men were treated with 46 Gy2 of external beam radiotherapy targeted at the prostate and regional lymph nodes. After this approach, 198 men received LDR-PB, and very small radioactive seeds were implanted in their prostate glands. The remaining 200 patients were randomized to dose-escalated external beam radiation therapy (DE-EBRT) and were addressed with an additional 3
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Isaura Santos graduated with a BS in Cell and Molecular Biology from Universidade Nova de Lisboa and a MA in Communication, Culture and Information Technologies from University Institute of Lisbon (ISCTE-IUL). Her professional interests include science communication, public awareness of science and communication of science through entertainment.

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