Novel Gene Family Linked to Prostate Cancer Development

Novel Gene Family Linked to Prostate Cancer Development
A new study recently published in the journal Nature Genetics revealed a molecular portrait of the spatial heterogeneity of localized, multifocal prostate tumors in patients, disclosing a new gene family that drives cancer development. The study is entitled Spatial genomic heterogeneity within localized, multifocal prostate cancer” and was conducted by an international research team led by researchers at the University of Toronto, the Ontario Institute for Cancer Research and the Princess Margaret Cancer Centre, University Health Network (UHN) in Canada. Prostate cancer is the second most common cancer in men with almost one million new cases diagnosed every year worldwide. It is a curable cancer that can range from slow-growing tumors to rapidly progressing aggressive tumors, which are more difficult to treat. In the study, researchers analyzed the molecular profile of 74 prostate cancer patients with a Gleason Score 7, which corresponds to a medium-grade cancer in terms of aggressiveness. Among them, multiple tumors from five patients who had their prostates surgically removed were submitted to whole-genome sequencing (23 tumor samples). The team conducted a careful detailed analysis of each tumor genetics and was able to assign specific “aggression scores”. Researchers found that even small tumors can contain aggressive cells that are able to change a patient’s prognosis. “Our research s
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